Top South African striker Shaun Bartlett looks likely to miss the country's vital World Cup qualifier against the Democratic Republic of Congo on September 5.
The Charlton Athletic striker injured his ankle in an English Premiership clash against Portsmouth at the weekend.
He looks likely be out of action for at least a week, which puts him in doubt for the DRC game.
"It doesn't look too good at all," Baxter is reported as saying in the Star. "For diverse reasons we can never get a settled team."
Although Bartlett was not at his best against Tunisia last week, he still remains Bafana Bafana's all time leading goal-scorer, and with the current lack of quality strikers in South African soccer, the 31-year-old is still crucial to the national team's plans.
Other injury concerns for the coach are that of two holding midfielders - Manchester United's Quinton Fortune and Benson Mhlongo of Wits, as well as long-term injury victim, Sibusiso Zuma.
"It's too soon for him (Zuma)," said Baxter. "I'm waiting with baited breath (with regards to the availability of Fortune and Mhlongo.)"